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Miệng chứa nhiều đầu mút thần kinh cảm giác, cũng là nơi chứa nhiều niêm mạc nên rất nhạy cảm với bất kỳ can thiệp răng miệng nào.Thận trọng dùng thuốc trên bệnh nhân bị nghiện rượu hay có nhiễm độc do rượu.Trong thời gian sử dụng thuốc, người bệnh tuyệt đối tu
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